Vanderbilt's quarterback Diego Pavia (2) celebrates his go-ahead touchdown against Missouri during their game at FirstBank Stadium in Nashville, Tenn., Saturday, Oct. 25, 2025.

After several weeks of high-profile college football Saturdays headlined by matchups between ranked teams, Week 10 doesn't initially look quite as appealing on paper.

But as college football has shown time and time again, that paper may very well end up getting crumpled and thrown away after a sport that reliably delivers thrills does so yet again.

The lengthy slate includes just three games between teams that are both ranked in the latest US LBM Coaches Poll, though each of those clashes has important College Football Playoff ramifications.

Diego Pavia will look to continue his magic and advance his No. 11 Vanderbilt team's playoff dreams when the Commodores hit the road to take on No. 19 Texas. Fresh off a blowout win over Colorado, No. 24 Utah will host No. 17 Cincinnati in a game getting the ESPN "College GameDay" treatment. No. 14 Tennessee will host a No. 18 Oklahoma team hoping to avoid a third loss that would likely end its playoff hopes.

The intrigue goes beyond that trio of games. No. 1 Ohio State will try to remain unbeaten when it hosts a reeling Penn State team in a contest that has lost much of its luster over the past month. No. 9 Miami will travel to SMU in what will likely be an elimination game for the race to the ACC championship. No. 5 Georgia and Florida will meet in Jacksonville in the latest edition of their longtime, always simmering rivalry.

Here is an early look at picks, predictions and odds for all of the Week 10 games on the 2025 college football schedule:

College football Week 10 game predictions, picks

Odds courtesy of BetMGM as of Sunday, Oct. 26

No. 1 Ohio State vs. Penn State

  • Date: Saturday, Nov. 1
  • Time: Noon ET
  • Location: Ohio Stadium (Columbus, Ohio)
  • Spread: Ohio State -20.5

Prediction: Ohio State 36, Penn State 13

No. 2 Indiana vs. Maryland

  • Date: Saturday, Nov. 1
  • Time: 3:30 p.m. ET
  • Location: SECU Stadium (College Park, Maryland)
  • Spread: Indiana -22.5

Prediction: Indiana 41, Maryland 17

No. 5 Georgia vs. Florida

  • Date: Saturday, Nov. 1
  • Time: 3:30 p.m. ET
  • Location: EverBank Stadium (Jacksonville, Florida)
  • Spread: Georgia -7.5

Prediction: Georgia 33, Florida 16

No. 7 Georgia Tech vs. NC State

  • Date: Saturday, Nov. 1
  • Time: 7:30 p.m. ET
  • Location: Carter-Finley Stadium (Raleigh, North Carolina)
  • Spread: Georgia Tech -6.5

Prediction: Georgia Tech 30, NC State 24

No. 8 Ole Miss vs. South Carolina

  • Date: Saturday, Nov. 1
  • Time: 7 p.m. ET
  • Location: Vaught-Hemingway Stadium (Oxford, Mississippi)
  • Spread: Ole Miss -13.5

Prediction: Ole Miss 38, South Carolina 23

No. 9 Miami vs. SMU

  • Date: Saturday, Nov. 1
  • Time: Noon ET
  • Location: Gerald J. Ford Stadium (Dallas, Texas)
  • Spread: Miami -10.5

Prediction: Miami 31, SMU 27

No. 11 Vanderbilt vs. No. 19 Texas

  • Date: Saturday, Nov. 1
  • Time: Noon ET
  • Location: Darrell K Royal-Texas Memorial Stadium (Austin, Texas)
  • Spread: Texas -2.5

Prediction: Vanderbilt 24, Texas 20

No. 12 Notre Dame vs. Boston College

  • Date: Saturday, Nov. 1
  • Time: 3:30 p.m. ET
  • Location: Alumni Stadium (Chestnut Hill, Massachusetts)
  • Spread: Notre Dame -28.5

Prediction: Notre Dame 45, Boston College 10

No. 13 Texas Tech vs. Kansas State

  • Date: Saturday, Nov. 1
  • Time: 3:30 p.m. ET
  • Location: Bill Snyder Family Stadium (Manhattan, Kansas)
  • Spread: Texas Tech -7

Prediction: Texas Tech 31, Kansas State 30

No. 14 Tennessee vs. No. 18 Oklahoma

  • Date: Saturday, Nov. 1
  • Time: 7:30 p.m.
  • Location: Neyland Stadium (Knoxville, Tennessee)
  • Spread: Tennessee -3.5

Prediction: Tennessee 34, Oklahoma 23

No. 15 Virginia vs. Cal

  • Date: Saturday, Nov. 1
  • Time: 3:45 p.m. ET
  • Location: California Memorial Stadium (Berkeley, California)
  • Spread: Virginia -4

Prediction: Cal 27, Virginia 20

No. 16 Cincinnati vs. No. 24 Utah

  • Date: Saturday, Nov. 1
  • Time: 10:15 p.m. ET
  • Location: Rice-Eccles Stadium (Salt Lake City, Utah)
  • Spread: Utah -7

Prediction: Utah 24, Cincinnati 23

No. 17 Louisville vs. Virginia Tech

  • Date: Saturday, Nov. 1
  • Time: 3 p.m. ET
  • Location: Lane Stadium (Blacksburg, Virginia)
  • Spread: Louisville -10.5

Prediction: Virginia Tech 27, Louisville 23

No. 21 Michigan vs. Purdue

  • Date: Saturday, Nov. 1
  • Time: 7 p.m. ET
  • Location: Michigan Stadium (Ann Arbor, Michigan)
  • Spread: Michigan -20.5

Prediction: Michigan 31, Purdue 20

No. 22 Houston vs. West Virginia

  • Date: Saturday, Nov. 1
  • Time: Noon ET
  • Location: TDECU Stadium (Houston, Texas)
  • Spread: Houston -14.5

Prediction: Houston 38, West Virginia 14

No. 23 Navy vs. North Texas

  • Date: Saturday, Nov. 1
  • Time: Noon. ET
  • Location: DATCU Stadium (Denton, Texas)
  • Spread: North Texas -6.5

Prediction: North Texas 40, Navy 38

No. 25 Memphis vs. Rice

  • Date: Friday, Oct. 31
  • Time: 7 p.m. ET
  • Location: Rice Stadium (Houston, Texas)
  • Spread: Memphis -14.5

Prediction: Memphis 35, Rice 24

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This article originally appeared on USA TODAY: College football Week 10 games, picks, odds and predictions for every top-25 matchup

Reporting by Craig Meyer, USA TODAY NETWORK / USA TODAY

USA TODAY Network via Reuters Connect