Familiar matchups abound on the NFL Week 10 schedule as there are half a dozen divisional games you can make Week 10 NFL picks on. The highlight of that slate is Rams vs. 49ers, which has L.A. as 3.5-point road favorites, per the latest NFL odds. The Niners won, 26-23, when the two met in early October, but the Rams had won the three prior matchups. This is one of four games with a Week 10 NFL spread that favors the road team.

Other divisional contests include Bills vs. Dolphins (+8.5), Texans vs. Jaguars (+1.5) and Saints vs. Panthers (-4.5). The entire NFC West will do battle as Seahawks vs. Cardinals has Seattle favored by 6.5 points, per the Week 10 NFL lines, with both teams coming off primetime games. The non-divisional slate is highlighted by Steelers vs. Chargers (-3) on Sunday ni

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