Philadelphia Eagles quarterback Jalen Hurts (1) rushes the ball against the Green Bay Packers during the second half of their 2025 NFC wild-card playoff game.

The halfway point of the 2025 NFL regular season came and went, with the NFL trade deadline not far behind, and the league feels more wide open than expected as the playoff push really begins. Perhaps Week 10 will offer some more clues about how the standings will shake out because there are a bunch of intriguing matchups and division games on the schedule.

The potential drama starts in Munich, Germany on Sunday morning when the NFL wraps up its international slate with the Atlanta Falcons vs. Indianapolis Colts. The early Sunday afternoon slate is highlighted by a showdown of unlikely contenders when Drake Maye and the New England Patriots visit Baker Mayfield and the Tampa Bay Buccaneers.

An NFC West matchup between the Arizona Cardinals and Seattle Seahawks should be a better late Sunday afternoon game than the 2024 NFC Championship rematch pitting the wounded Washington Commanders against the Detroit Lions. But the marquee game of Week 10 doesn't kick off come until Monday Night Football, when the Green Bay Packers host the Super Bowl champion Philadelphia Eagles in a 2024 NFC playoff rematch and potential 2025 playoff preview.

Here's a look at the early expert picks and predictions for every game during Week 10 of the 2025 NFL season:

NFL Week 10 game predictions, picks

Odds courtesy of BetMGM as of Tuesday, Nov. 4 at 10:50 a.m. ET.

Las Vegas Raiders vs. Denver Broncos

  • Date: Thursday, Nov. 6
  • Time: 8:15 p.m. ET
  • Location: Empower Field at Mile High
  • TV: None
  • Streaming: Amazon Prime, NFL+
  • Spread: Broncos (-9)

Sporting News: Broncos 33, Raiders 18

It's a high spread for a division game – but the Broncos' pass rush will force a few turnovers from Geno Smith. The Raiders have been outscored 112-30 in their last three road losses. Tight end Brock Bowers – who had 127 yards and three TDs last week – didn't play in two of those losses. It still feels like the Broncos have control at home – even if they are 1-3 against the spread when favored by more than seven points this season.

Arizona Republic: Broncos 27, Raiders 13

"The Broncos currently have a 6-game win streak, tied for the longest in the NFL. It will be seven games after Thursday Night Football in NFL Week 10. Denver's defense will feast on Geno Smith."

Atlanta Falcons vs. Indianapolis Colts

  • Date: Sunday, Nov. 9
  • Time: 1 p.m. ET
  • Location: Olympic Stadium (Berlin, Germany)
  • TV: NFL Network
  • Streaming: Fubo, NFL Sunday Ticket, NFL+
  • Spread: Colts (-5.5)

CBS Sports: Colts 27, Falcons 20

"This is going to be a Jonathan Taylor game. If you don't want (Daniel) Jones to turn it over, then you just keep giving it to Taylor ... The Falcons have given up more than 100 rushing yards in seven of their eight games this year ... Atlanta is 3-0 this season when Robinson gets 15 carries or more in a game, but the Falcons don't care. They just refuse to hand him the ball. He got just nine carries in a Week 8 loss to the Dolphins and he got 12 carries on Sunday against New England."

BetMGM: Take Falcons, but be cautious

Laying this many points with Daniel Jones feels dangerous, and the public is ALL OVER Indianapolis. ... Pittsburgh showed that a decent pass rush can get to Jones. If there’s hope for the Falcons, it’s that the offense takes a lead and uses the pass rush to retain the advantage. The glaring concern with the Falcons? Atlanta has struggled to stop the run."

New Orleans Saints vs. Carolina Panthers

  • Date: Sunday, Nov. 9
  • Time: 1 p.m. ET
  • Location: Bank of America Stadium (Charlotte, North Carolina)
  • TV: FOX
  • Streaming: Fubo, NFL Sunday Ticket
  • Spread: Panthers (-5.5)

Sporting News: Panthers 24, Saints 15

"The Panthers proved against the Packers that they can be a playoff team – and Rico Dowdle has three games with 100 or more rushing yards in the last five weeks. The Saints allow 129.4 rushing yards per game, too. Carolina is 3-1 straight up at home this season.

Sports Illustrated: Saints cover

"Now is the perfect time to sell high on the Panthers as they take on a hungry Saints team that is looking to deliver a win for their rookie quarterback, Tyler Shough, who looked solid in his first career start against one of the best defenses in the league. The Saints rank just one spot behind the Panthers in Net Yards per Play."

New York Giants vs. Chicago Bears

  • Date: Sunday, Nov. 9
  • Time: 1 p.m. ET
  • Location: Soldier Field (Chicago)
  • TV: FOX
  • Streaming: Fubo, NFL Sunday Ticket, NFL+
  • Spread: Bears (-3.5)

Arizona Republic: Bears 24, Giants 21

"The Bears' offense feasted on Cincinnati's porous defense in Week 9. Chicago won't score 47 points in this game like it did in the win over the Bengals, but Caleb Williams and company will be able to outscore Jaxson Dart and the Giants."

Sporting News: Bears 27, Giants 21

"The Giants have scored just 16 points per game the last two weeks, and the Bears average 27 points per game at home. Will New York's pass rush be able to land against Caleb Williams, who has taken just four sacks in the last three games?"

Baltimore Ravens vs. Minnesota Vikings

  • Date: Sunday, Nov. 9
  • Time: 1 p.m. ET
  • Location: U.S. Bank Stadium (Minneapolis)
  • TV: FOX
  • Streaming: Fubo, NFL Sunday Ticket
  • Spread: Ravens (-4)

CBS Sports: Vikings 27, Ravens 24

"The Ravens have given up the fifth-most passing yards per game in the NFL this year and that could be a problem for a team that's about to face a Vikings offense that has one of the top receivers in the NFL in Justin Jefferson. ... The Ravens have NEVER won in Minnesota and ... that streak somehow continues on Sunday."

Sports Illustrated: Ravens cover, start win streak

"The Baltimore Ravens look to finally be playing at the level that everyone expected them to be playing at coming into this season. It was a disastrous start to their 2025 campaign, but after a Week 7 BYE that allowed them to reset and get healthy, the Ravens have now strung together two straight wins by a combined score of 58-22. Not only did Lamar Jackson look as efficient as ever last Thursday night, but the Ravens' defense has looked as good as they have all season."

Jacksonville Jaguars vs. Houston Texans

  • Date: Sunday, Nov. 9
  • Time: 1 p.m. ET
  • Location: NRG Stadium (Houston)
  • TV: CBS
  • Streaming: Fubo, NFL Sunday Ticket
  • Spread: Texans (-1)

Arizona Republic: Texans 21, Jaguars 20

"This game is a must-win for the Texans and C.J. Stroud's status looms large for Houston. Houston will edge Jacksonville with a strong defensive effort. And when we say edge, we mean edge."

Sporting News: Jaguars 23, Texans 18

"Will C.J. Stroud (concussion) play? That would alter the line if Davis Mills is the starter for the Texans. Jacksonville won the first meeting 17-10 in Week 3 – and another defensive struggle seems inevitable between these AFC South rivals, whether Stroud plays or not."

Buffalo Bills vs. Miami Dolphins

  • Date: Sunday, Nov. 9
  • Time: 1 p.m. ET
  • Location: Hard Rock Stadium (Miami Gardens, Florida)
  • TV: CBS
  • Streaming: Fubo, NFL Sunday Ticket
  • Spread: Bills (-9.5)

Covers.com: Dolphins cover big spread

"The Bills are ripe for a letdown after the vengeful win over Kansas City, and with Tampa Bay coming to Orchard Park in Week 11, Buffalo could keep it simple against a terrible Miami defense. That means plenty of handoffs and drawn-out possessions, with the Bills chewing up the clock."

Sports Illustrated: Bills win big

"The Bills have seemingly fixed their defensive issues over the BYE week and are now coming off impressive wins against both the Panthers and the Bills. Their offense continues to roll, but if their defense can shut down (Patrick) Mahomes and the rest of the Chiefs, the Dolphins shouldn't be much of an issue for them."

Cleveland Browns vs. New York Jets

  • Date: Sunday, Nov. 9
  • Time: 1 p.m. ET
  • Location: MetLife Stadium (East Rutherford, New Jersey)
  • TV: CBS
  • Streaming: Fubo, NFL Sunday Ticket
  • Spread: Jets (-2)

Sporting News: Browns 19, Jets 16

"The Jets have allowed 31 sacks this season – the fourth most in the NFL. That is a frightening trend facing Cleveland edge rusher Myles Garrett – who has 10 sacks this season. ... The Browns average 12.5 points on the road. Dillon Gabriel has avoided sacks, but can he avoid turnovers on the road in a defensive struggle?"

ESPN: Browns win low-scoring game

"Take the Browns and the points because of Jim Schwartz's defense. Pressure the quarterback and play press coverage. Cleveland will keep the score low and take the ball away to create field position here."

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New England Patriots vs. Tampa Bay Buccaneers

  • Date: Sunday, Nov. 9
  • Time: 1 p.m. ET
  • Location: Raymond James Stadium (Tampa, Florida)
  • TV: CBS
  • Streaming: Fubo, NFL Sunday Ticket
  • Spread: Buccaneers (-2.5)

CBS Sports: Bucs 27, Patriots 24

"Both of these teams are surrendering less than 95 yards per game on the ground ‒ the Patriots have given up the fewest rushing yards per game in the NFL this year ‒ so this feels like a matchup where both quarterbacks are going to be throwing it a lot. If the Patriots are going to win, they're likely going to need Maye to throw the ball, but they haven't been able to win when he's forced to throw the ball. You know who does win when he's forced to throw the ball? Baker Mayfield. The Bucs are 3-2 this season when he throws the ball 30 or more times."

BetMGM: Patriots are strong underdog pick

"Tampa Bay’s lone win against a good passing offense – at Seattle – came because the Bucs scored 38 against an injury-riddled Seahawks secondary. Most recently, the Bucs earned a 23-3 win over the Saints despite 212 yards of offense. Injuries remain a concern for this team, which has massively overperformed expectations. Tampa Bay enters this game 7-2 with the point differential of a 4.5-3.5 team. Injuries have contributed to that record, but Tampa Bay has only won by three or more twice this season. Lastly, the number is a bit of a head scratcher. In Week 2, the Patriots closed a two-point road dog to Miami. Are we actually saying the Bucs are only a half-point better than the Dolphins?"

Arizona Cardinals vs. Seattle Seahawks

  • Date: Sunday, Nov. 9
  • Time: 4:05 p.m. ET
  • Location: Lumen Field (Seattle)
  • TV: CBS
  • Streaming: Fubo, Paramount+, NFL Sunday Ticket, NFL+
  • Spread: Seahawks (-6.5)

Arizona Republic: Seahawks 27, Cardinals 17

"The Seahawks beat the Cardinals earlier this season in Arizona, 23-20. This game in Seattle won't be as close. Sam Darnold and the Vikings have their sights set on the NFC West title."

Sports Illustrated: Seattle covers

"People are starting to catch on to how good this Seattle Seahawks team is, but ... there's some value betting on them at their current price point in the betting market. The Seahawks are the No. 1-ranked team in the NFL according to DVOA, ranking fourth offensively, second defensively, and first in special teams."

Los Angeles Rams vs. San Francisco 49ers

  • Date: Sunday, Nov. 9
  • Time: 4:25 p.m. ET
  • Location: Levi's Field (Santa Clara, California)
  • TV: FOX
  • Streaming: Fubo, NFL Sunday Ticket
  • Spread: Rams (-3.5)

BetMGM: Take the Rams

"San Francisco finished its road trip 1-1. However, both games produced concerning defensive performances. Both Houston and the Giants scored 24 or more against the Niners defense. As it stands, that unit is facing myriad injuries. Nick Bosa and Fred Warner are done for the year. Bryce Huff is missing time. And now the team has to contend with a Mykel Williams injury. That should cause trouble against a good Rams offense."

Action Network: Rams win in revenge spot

These NFC West rivals are trending in opposite directions. The 49ers may be 6-3 after beating the Giants on Sunday, but they somehow keep taking on injuries after losing Mykel Williams, who was their best defensive lineman left. ... On the quarterback front, it doesn't sound like Brock Purdy's close to being activated either. The Rams have a case for the title of best team in the NFL. ... In the past, you wanted to back Kyle Shanahan when he faced Sean McVay ... but the Rams covered in four straight games until the disaster on Thursday Night Football a month ago when L.A. lost to the 49ers backups. The Rams will be focused and ready in this revenge spot."

Detroit Lions vs. Washington Commanders

  • Date: Sunday, Nov. 9
  • Time: 4:25 p.m. ET
  • Location: Northwest Stadium (Landover, Maryland)
  • TV: FOX
  • Streaming: Fubo, NFL Sunday Ticket, NFL+
  • Spread: Lions (-8.5)

Detroit Free Press: Lions 34, Commanders 24

"The Lions may have underestimated their previous opponent, or at least it seemed that way against the Vikings, who consistently played the bully at the line of scrimmage while snuffing the Lions' run game. But a ground attack may not be needed this week with the Commanders sporting the fourth-worst pass defense in the NFL. Sam Darnold just lit them up for four first-half touchdown passes. Even on the road and still with injuries to key players, the Lions should cruise to a win."

New York Post: Lions win big

"We’ve seen the Marcus Mariota experiment in Washington, and it’s been bad. Mariota has played in parts of five games for the Commanders, four losses. They are losing by an average deficit of 18.5 points in the last four games that he’s played in. Washington looked absolutely heartbroken when Daniels went down in the middle of a blowout loss. ... This is a good buy-low spot on the Lions, who had flukey special teams mistakes to blame for their Week 9 loss to the Vikings."

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Pittsburgh Steelers vs. Los Angeles Chargers

  • Date: Sunday, Nov. 9
  • Time: 8:20 p.m. ET
  • Location: SoFi Stadium (Inglewood, California)
  • TV: NBC
  • Streaming: Peacock, Fubo, NFL+
  • Spread: Chargers (-3)

CBS Sports: Chargers 34, Steelers 27

"In Week 9, the Steelers stopped the NFL's leading passer (Daniel Jones), but that only worked because the Colts' offense revolves around Jonathan Taylor and if you stop him, you can stop Indy. With the Chargers, they don't need their running game to beat you, they just need (Justin) Herbert. As a matter of fact, the Chargers are 1-2 this year when they rush for 150 yards or more, so they're actually worse when they run the ball well. For the Chargers to win this game, they need Hebert to pick apart the Steelers and not turn over the football."

BetMGM: Steelers have the advantage

"Pittsburgh enters SNF with ... glaring advantages. First is their ability to rush the passer. Teryl Austin’s defense ranks second in pass-rush win rate and fourth in PFF’s pressure grades. The Chargers rank 30th in each of the corresponding offensive metrics. It’s also an offensive line that could operate without Joe Alt AND Mekhi Becton, further complicating the matter. This season, Los Angeles is 1-2 with Alt missing the game vs. 5-1 when he plays. At Tennessee, Alt was carted off the field, suggesting another spell on the sidelines."

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Philadelphia Eagles vs. Green Bay Packers

  • Date: Monday, Nov. 10
  • Time: 8:15 p.m. ET
  • Location: Lambeau Field (Green Bay, Wisconsin)
  • TV: ABC, ESPN
  • Streaming: Fubo, NFL Sunday Ticket, NFL+
  • Spread: Packers (-2.5)

ESPN: Eagles win outright

"Many will view the Packers losing at home to the lowly Carolina Panthers ‒ a team that now has the same number of wins ‒ as aberrant. They should. That loss shouldn't happen, and the Packers will probably play better against the defending Super Bowl champs. That doesn't change the fact that the Eagles have a much better offense, led by a consistent, mistake-free QB, explosive RB, dominant WRs and TD-scoring TE. The Packers have a reckless QB and lack WRs, and they just lost their starting tight end for the season. The Eagles will win this game outright."

New York Post: Eagles win

"The Packers are expected to be without Matthew Golden, who exited Sunday with a shoulder injury and did not return. Green Bay will also be missing Tucker Kraft, who is now out with a torn ACL. The Eagles, meanwhile, have made several trades since we last saw them, including bringing in some defensive help in Jaire Alexander and Jaelan Phillips. Those aren’t massive moves by any means, but the Eagles are adding while the Packers are actively losing guys."

This article originally appeared on USA TODAY: NFL Week 10 game picks: Odds and predictions for every matchup

Reporting by Mark Giannotto, USA TODAY / USA TODAY

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