A UPS cargo plane crashed and exploded Tuesday while taking off from an airport in Louisville, Kentucky, killing at least seven people and injuring numerous others.

Watch aerial footage of the initial scene in the video player above.

The plane crashed about 5:15 p.m. as it was departing for Honolulu from Louisville's Muhammad Ali International Airport, the Federal Aviation Administration said.

Video showed flames on the plane's left wing and a trail of smoke. The plane then lifted slightly off the ground before crashing and exploding in a huge fireball. Video also revealed portions of a building’s shredded roof next to the end of the runway.

The death toll had risen to at least seven Tuesday night, and four of those killed were not on the plane, officials said.

Among 11 people who wer

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