DEDHAM, Mass. — Prosecutors Monday argued a Massachusetts man was responsible for the grisly murder of his wife who disappeared more than two years ago while his lawyers insisted the man panicked after she suddenly died in bed.

Ana Walshe, a real estate agent who immigrated from Serbia, was last seen early on Jan. 1, 2023, following a New Year’s Eve dinner at her Massachusetts home. Her body has never been found. Her husband, Brian Walshe, faces a first-degree murder charge, after agreeing to plead guilty last month to lesser charges of misleading police and willfully disposing of a human body in violation of state law.

“We will prove the defendant guilty beyond a reasonable doubt of the premeditated murder of his wife Ana Walshe,” Assistant District Attorney Gregory Connor said in his o

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