The No. 9 Iowa State Cyclones (8-0) and No. 1 Purdue Boilermakers (8-0) meet Saturday at Mackey Arena in West Lafayette, Indiana. Tip-off is set for noon ET (CBS). Let's analyze BetMGM Sportsbook's NCAA basketball odds around the Iowa State vs. Purdue odds and make our expert college basketball picks and predictions for the best bets.

Iowa State throttled the Alcorn State Braves 132-68 Wednesday, scoring 65 or more points in both halves. The Cyclones covered as a 42.5-point favorite as the Over (151) cashed. Iowa State has had one top-25 game this season, beat the No. 22 St. John's Red Storm 83-82 on Nov. 24 yet failing to cover as a 2.5-point favorite in that battle. The Cyclones are 6-2 against the spread (ATS) on the season.

Purdue beat the Rutgers Scarlet Knights 81-65 Tues

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