When Mayor Larry Agran moved to Irvine in 1975, it was to support his wife in her breakthrough admission to the UC Irvine School of Medicine as part of one of the first classes to include women.

Agran has since served on the Irvine City Council on and off for the better part of five decades — and from the dais, witnessed the city’s health-care evolution.

He was on the council when the city’s first hospital, Irvine Medical Center — later Irvine Regional Hospital — opened in 1988 at Alton Parkway and Sand Canyon Road and when it was acquired in 2010 by Hoag . In 2008, Agran and residents saw Kaiser Permanente open its $370 million hospital complex across the street .

But this is an even bigger month for Irvine.

The city is helping celebrate City of Hope and UCI Health as they o

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