On Saturday night, college football fanatics will be treated to a titanic clash between the top two teams in the country: Ohio State (12-0, 9-0 Big Ten) and Indiana (12-0, 9-0 Big Ten).

What’s on the line?

This game will not only determine the Big Ten champion, but also which team will secure the No. 1 overall seed in the CFP, which team will be the last remaining undefeated team in the country, and potentially, which quarterback will win the Heisman Trophy.

The Ohio State Buckeyes are 4.5-point favorites over the Hoosiers at Lucas Oil Stadium, while the over/under rests at 48.5 points.

Will the Hoosiers upset Ohio State and secure the top seed in the CFP? Check out our Ohio State vs. Indiana predictions, picks, and best bets for the Big Ten Championship.

Ohio State vs. Indiana predic

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