The defending Super Bowl champion Philadelphia Eagles will open their campaign against the Dallas Cowboys in the 2025 NFL Kickoff Game on Thursday, Sept. 4. Philadelphia went 14-3 in the regular season and capped its playoff run with a 40-22 win over Kansas City in the Super Bowl. Dallas, who traded Micah Parsons to the Packers just a week before the opener, missed the playoffs last year with a 7-10 record, as quarterback Dak Prescott played just eight games before suffering a season-ending hamstring injury. This is the first Week 1 meeting between these NFC East rivals since 2000.

Kickoff from Lincoln Financial Field in Philadelphia is set for 8:20 p.m. ET on Thursday, Sept. 4. The Eagles favored by 7.5 points in the latest Eagles vs. Cowboys odds at FanDuel Sportsbook, while t

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