Joey Pollizze analyzes all 2025 fantasy football Week 2 defenses (DEF) -- streamers, sits/starts, and D/ST waiver wire pickups to add. His Week 2 rankings and tiers for all of the NFL defenses.

Welcome RotoBallers to our fantasy football defense streamers, starts and tiered rankings for Week 2 of the 2025 season! Every week of the fantasy season, this article will contain the best and worst defensive options. Each defense will be ranked No. 1 through No. 32 until the end of the fantasy football season. This will be your go-to stop for all defensive rankings and streamers for the entire year.

With the first week of the season officially in the books, we turn our attention to Week 2. We will break down each defense into six different rankings tiers and determine which defenses are the best

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