Los Angeles Chargers quarterback Justin Herbert (10) after the game against the Kansas City Chiefs at Corinthians Arena in Sao Paulo, Brazil.

The LA Chargers (1-0) and the Las Vegas Raiders (1-0) meet for a Week 2 matchup on Monday Night Football at Allegiant Stadium in Las Vegas, Nevada. Kickoff is scheduled for 10 p.m. ET (ESPN). Let's analyze BetMGM Sportsbook's NFL odds around the Chargers vs. Raiders odds and make our expert NFL picks and predictions for the best bets.

The Chargers picked up a 27-21 victory in Week 1 over the Kansas City Chiefs Sept. 5 in Brazil as 3-point underdog as the Over (46.5) just came through. The Bolts had 22 first downs, while posting a 7-of-13 mark on third-down efficiency. QB Justin Herbert looked like himself after being mostly banged up in 2024, as the Chargers went for 304 passing yards.

The Raiders headed East in Week 1, posting a 20-13 road victory against the New England Patriots as a 2.5-point underdog as the Under (44.5) connected. Las Vegas has 389 total yards, including 333 through the air in the team debut of QB Geno Smith. The Raiders need to clean up the penalties, after posting 9 infractions for 77 yards.

The Chargers swept the regular-season series between these AFC West rivals last season, with the Bolts winning 22-10 in L.A. as 3-point favorites on Sept. 8 as the Under (40.5) cashed, while winning 34-20 in Las Vegas as a 7-point favorite as the Over (41.5) connected. The Chargers are 5-3-1 against the spread (ATS) in the past 9 in the series, although the Raiders hold a 3-2 ATS advantage in the past 5 home meetings.

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Chargers at Raiders odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Sunday at 7:01 p.m. ET.

  • Moneyline (ML): Chargers -190 (bet $190 to win $100) | Raiders +155 (bet $100 to win $155)
  • Against the spread (ATS): Chargers -3.5 (-105) | Raiders +3.5 (-115)
  • Over/Under (O/U): 46.5 (O: -110 | U: -110)

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Chargers at Raiders injuries

Chargers

  • DB Elijah Molden (hamstring) out
  • LB Denzel Perryman (ankle) out
  • LB Del'Shawn Phillips (toe) questionable

Raiders

  • TE Brock Bowers (knee) questionable
  • OL Jackson Powers-Johnson (concussion) out

Chargers at Raiders picks and predictions

Prediction

Chargers 24, Raiders 18

Moneyline

The Chargers (-190) are a little on the expensive side, costing you nearly 2 times your potential return. That's too much risk for a singular bet, although it would be OK to bet with a boost, promo or as part of a multi-leg parlay.

AVOID, and look to the spread instead.

  • MONDAY NIGHT FOOTBALL: Best prop bets

Against the spread

The CHARGERS -3.5 (-105) took down the Chiefs in South America. That was impressive, but there is a lot of concern with the Chargers playing another road game within 8 days. The Bolts have had a lot of travel early on. While the flight from L.A. to Vegas isn't much, there could still be a bit of a hangover from the long trip to the southern hemisphere.

Of course, the Raiders also had a cross-country trek. While not as long, going to New England is a lengthy trip, too. We'll back the team which was more impressive last week, and that is L.A.

Over/Under

UNDER 46.5 (-110) is worth a look, again, because of all of the travel for both of these teams in the past week.

The Chargers had a long slog down to Brazil and back, while the Raiders had the trip to the Eastern Time Zone to face the Patriots. We could see a slow start before these teams start to get untracked in the second half.

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This article originally appeared on Sportsbook Wire: LA Chargers at Las Vegas Raiders odds, picks and predictions

Reporting by Daniel Dobish, Sportsbook Wire / Sportsbook Wire

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