Kansas City Chiefs at New York Giants odds, picks and predictions

Kansas City Chiefs tight end Travis Kelce (87) celebrates after a run against the Philadelphia Eagles during the game at GEHA Field at Arrowhead Stadium in Kansas City, Missouri.

The Kansas City Chiefs (0-2) and New York Giants (0-2) meet in Week 3 on Sunday Night Football. Kickoff from MetLife Stadium in East Rutherford, New Jersey, is set for 8:20 p.m. ET (NBC). Let's analyze BetMGM Sportsbook's NFL odds around the Chiefs vs. Giants odds and make our expert NFL picks and predictions for the best bets.

The Chiefs are 0-2 for the first time in QB Patrick Mahomes' career. They are coming off a 20-17 home loss to the Philadelphia Eagles in Week 2 as 1-point underdogs. The Under (47.5) cashed. Eagles QB Jalen Hurts and RB Saquon Barkley each rushed for a TD against the Chiefs. Mahomes was picked off once.

The Giants lost a thriller at the Dallas Cowboys 40-37 in OT in Week 1 as 5.5-point underdogs. QB Russell Wilson passed for 450 yards and 3 TDs, but his overtime INT led to Dallas' game-winning field goal. Rookie RB Cam Skattebo led the Giants with 45 rushing yards and a TD.

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Chiefs at Giants odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 8:17 a.m. ET.

Moneyline (ML): Chiefs -300 (bet $300 to win $100) | Giants +240 (bet $100 to win $240)
Against the spread (ATS): Chiefs -6 (-110) | Giants +6 (-110)
Over/Under (O/U): 45 (O: -110 | U: -110)

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Chiefs at Giants key injuries

Chiefs

DE Mike Danna (quad) out
CB Kristian Fulton (ankle) out
WR Xavier Worthy (shoulder) out

Giants

LB Darius Muasau (concussion, eye) out
DE Rakeem Nunez-Roches (foot) doubtful
PR Gunner Olszewski (back) questionable
OL Andrew Thomas (foot) questionable

Chiefs at Giantspicks and predictions

Prediction

Chiefs 27, Giants 17

Moneyline

Is anyone going to bet the Giants to make Mahomes go 0-3 to start the season? Both losses have been 1-score games to teams who were in the playoffs last season.

The Giants are not on that level. They have allowed over 430 yards of offense in both their games. They have not been able to run the ball, averaging 79 yards per game so far.

The Chiefs should win, but -300 odds are not worth the payout.

PASS.

Against the spread

The Giants are 1-1 ATS, covering the spread in their OT loss to the Cowboys. The Chiefs are 0-2 ATS.

The Giants are last in the league in yards allowed. The Chiefs have given up only 3.6 yards per rushing attempt through 2 games.

BET CHIEFS -6 (-110).

Over/Under

The Chiefs have a solid defense, so don't expect the Giants to be able to do much, especially in the run game.

The Chiefs are shorthanded at receiver with Rashee Rice suspended and Worthy injured, and they've looked slow and boring through their first 2 games.

BET UNDER 45 (-110).

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For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.