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The Arizona Cardinals will play the San Francisco 49ers in Week 3 of the 2025 NFL season.

Kickoff is scheduled for 4:25 p.m. ET on Sunday, September 21, 2025, at Levi's Stadium.

The game will be broadcast on FOX and can be streamed on NFL+.

Both the Cardinals and the 49ers enter the matchup with undefeated 2-0 records.

Week 3 of the 2025 NFL season continues with the Arizona Cardinals traveling to Levi's Stadium to take on the San Francisco 49ers on Sunday.

Here's what you need to know about how to watch the 49ers vs. the Cardinals , today's matchup , the NFL Week 3 schedule , TV lineup and more.

What time does San Francisco 49ers - Arizona Cardinals game start today, Sunday, Sept. 21, 2025? When is Cardinals-49ers NFL football game tonig

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