The Buffalo Bills will lock horns with the New Orleans Saints in Week 4 of the NFL season at Highmark Stadium on Sunday September 28. Kickoff is at 1 p.m. ET.

Following the Bills’ narrower-than-expected victory over the Dolphins on Thursday Night Football and the Saints’ blowout loss to Seattle on Sunday, Dimers’ analysts conducted preliminary simulations for the Bills vs. Saints in Week 4 .

The results were compared to current NFL odds from sportsbooks like Bet365 , DraftKings , and FanDuel , to inform the Bills-Saints preview below.

Saints vs. Bills betting preview

Utilize the interactive widget below to discover the current spread, total, and moneyline odds and probabilities for the Saints-Bills matchup at Highmark Stadium.

Game details

Key information on the Saints vs. Bi

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