The NFL is an any given Sunday type of league, but oddsmakers seem fairly certain that the Buffalo Bills will take care of business in Week 4.

Buffalo, set to host the New Orleans Saints, opened as a 16.5-point favorite for the matchup at Highmark Stadium. This is the most that Buffalo has been favored by since they were listed as 17.5 point favorites against the Houston Texans in 2021. The Bills would go on to defeat the Davis Mills-led Texans 40-0.

The Saints are winless through their first three games and are coming off a 44-13 loss to the Seattle Seahawks. In their loss to the Seahawks, the Saints made history.

Rod Walker of The New Orleans Advocate shared that the Saints were the first team in NFL history to gain 280-plus yards, give up fewer than 330 yards, not lose the turno

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