Keith Urban has cancelled an upcoming stop on his High and Alive World Tour.

The crooner is unable to perform his scheduled concert in Greenville, South Carolina, on Thursday due to a bout of laryngitis.

The show's venue, Bon Secour Wellness Arena, announced the cancellation on social media, explaining that Urban has been placed on complete vocal rest by his doctor.

"Keith Urban has been advised by his longtime laryngologist, Dr Gaelyn Garrett from the Vanderbilt Voice Centre, to cancel his performance in Greenville, SC tomorrow night at Bon Secours Wellness Arena due to laryngitis which began earlier this week," the statement read.

"He has been placed on complete vocal rest and Dr Garrett is optimistic that he will be back onstage for his (17 October) Nashville show."

Of the cancellation, Urban was quoted: "Hey Greenville, I'm so, so sorry to have to cancel the show. I know all the logistics it takes to get to a concert these days, and I've never taken any of that, or any of YOU, for granted. I'm looking forward to getting back there when we can!"

Urban's apology to his fans for missing this show marks one of the first public statements he's made since news broke that he and wife Nicole Kidman are divorcing.

News of the couple's separation first broke in late September.