LOUISVILLE, Ky. — The University of Louisville will open its 2026 football season with a neutral-site matchup against Ole Miss, the schools announced Wednesday.

The game will be played Sept. 5 or 6 at Nissan Stadium in Nashville and will air nationally on ESPN. It will mark the second meeting between the programs, both at neutral sites.

“We are excited to partner with Ole Miss, ESPN, and Nashville Sports Council to bring this season-opening matchup to Nashville,” said UofL Director of Athletics/Vice President Josh Heird. “This contest presents a tremendous opportunity for our program, our student-athletes, and our fans. Nashville is home to a strong Cardinals presence, and showcasing Louisville Football in a premier venue on a national stage is something we wholeheartedly embrace.”

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